May 31, 2021

Paper on MKK3 expression and outcomes in breast cancer for African American women

In a paper published in the Journal of Translational Medicine our computational analysis of breast cancer histology provides an additional endpoint in correlating MKK3 expression and clinical outcomes in African American women. African American women experience a twofold higher incidence of triple-negative breast cancer (TNBC) and are 40% more likely to die from breast cancer than women of other ethnicities. However, the molecular bases for the survival disparity in breast cancer remain unclear, and no race-specific therapeutic targets have been proposed. To address this knowledge gap, we performed a systematic analysis of the relationship between mRNA expression and clinical outcomes determined for The Cancer Genome Atlas (TCGA) breast cancer patient cohort.